The Effects of Navelbine Application as a Single Agent and with Tamoxifen, Epirubicin or Carboplatin on Growth Kinetics of Fm3a Cells

نویسنده

  • Mehmet TOPÇUL
چکیده

In this study, after investigation of cytotoxic effects of Navelbine on tumour derived cells, the most efficient drug or drug combinations were explored using Navelbine+Tamoxifen, Navelbine+Epirubicin and Navelbine+Carboplatin. FM3A cells derived from C3H mouse mammary carcinoma were used in this investigation. Growth rate, mitotic index, labelling index and as being cell kinetics parameters were evaluated in the experiments. Although Navelbine application on FM3A cell cultures was successful, Tamoxifen application showed better experimental results. Therefore Tamoxifen was indicated as decreasing cell kinetics parameters. If drugs were considered according to their effects on cultures, Epirubicin and Navelbine were also efficient respectively compared Tamoxifen application. Carboplatin application did not change growth kinetics of FM3A cells. When drug combinations were applied on FM3A cell cultures, Navelbine+Epirubicin combination on cell kinetics parameters was more effective than the others. Navelbine+Tamoxifenwas indicated as a second effective combination.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

متن کامل

The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

متن کامل

Antiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

متن کامل

Antiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

متن کامل

Effects of Flavonoid Fractions from Calendula officinalis Flowers in Parent and Tamoxifen Resistant T47D Human Breast Cancer Cells

      Three major flavonoid fractions were separated from a methanol extract of Calendula officinalis flowers by preparative TLC. These fractions were evaluated for the inhibition of parent and tamoxifen resistant T47D human breast cancer cells. We also examined the effect of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014