The Effects of Navelbine Application as a Single Agent and with Tamoxifen, Epirubicin or Carboplatin on Growth Kinetics of Fm3a Cells

In this study, after investigation of cytotoxic effects of Navelbine on tumour derived cells, the most efficient drug or drug combinations were explored using Navelbine+Tamoxifen, Navelbine+Epirubicin and Navelbine+Carboplatin. FM3A cells derived from C3H mouse mammary carcinoma were used in this investigation. Growth rate, mitotic index, labelling index and as being cell kinetics parameters were evaluated in the experiments. Although Navelbine application on FM3A cell cultures was successful, Tamoxifen application showed better experimental results. Therefore Tamoxifen was indicated as decreasing cell kinetics parameters. If drugs were considered according to their effects on cultures, Epirubicin and Navelbine were also efficient respectively compared Tamoxifen application. Carboplatin application did not change growth kinetics of FM3A cells. When drug combinations were applied on FM3A cell cultures, Navelbine+Epirubicin combination on cell kinetics parameters was more effective than the others. Navelbine+Tamoxifenwas indicated as a second effective combination.